What Is a High-Grade Squamous Intraepithelial Lesion?

CIN terminology is a pathological diagnosis that was widely used in the 1970s and 1980s. However, a large number of studies in the past 20 years have revealed that cervical cancer and precancerous lesions are related to HPV infection. Further research has found that CIN is not a continuous single lesion of varying degrees, but can be divided into two types of clinical pathological processes with significant differences: low Mild and highly diseased.

Cervical squamous epithelial lesion

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CIN terminology was widely used in the 1970s and 1980s

(One)

CIN terminology was widely used in the 1970s and 1980s

A prominent contributor to cervical cytology diagnosis was Dr. George Papanicolaou (1883 ~ 1962), who has been in use for decades until the establishment of the more comprehensive cervical cytology standard The Bethesda System in 1991.

At the end of the 20th century, there were three important innovations in cervical cytology:

1. Innovative diagnostic theory The traditional Pap classification is replaced by TBS. Descriptive diagnosis based on cell morphology, combined with background, specimen volume and nature, and production techniques, etc., to comprehensively evaluate lesions;

2. Production technology innovation automatic

(I) Definition:

The International Federation of Obstetrics and Gynecology (FIGO) believes that the depth of infiltration is less than 5mm, and the Gynecologic Oncology Society considers that the depth of infiltration is less than 3mm, and the transverse width is less than 7mm.

The practice of cervical scraping: After fully exposing the outer cervix, rotate the scraper around the outer cervix for 360 degrees, and gently scrape the mucous membranes and secretions there. The removed secretions were evenly spread on numbered glass slides and immediately fixed in 95% ethanol for 15 minutes. After removal, they were stained by pasteurization.

Cervical scraping: It is an important method for screening early cervical cancer. It is also called "anti-cancer smear". There are two types of reports: graded diagnosis and descriptive diagnosis. At present, most hospitals in China still use hierarchical diagnosis, and Pap classification classification is commonly used in clinical practice:

Pap : Normal;

Pap II: Inflammation, which refers to the obvious heterogeneity of individual nuclei, but does not support malignancy, and the rest are A;

Pasteur III: Suspected cancer;

Pap IV: severe suspicious cancer.

Pasteur V: Cancer.