What Is a Histiocytic Sarcoma?

Malignant fibrohistiocytoma, also known as (malignant histiocytoma), is the most common soft tissue tumor in the elderly. Its swelling malignant fibrous histiocytoma cells are generally composed of histocytes and fibroblasts (fibrohistiocytoma), and rarely all are composed of histiocytic cells (histiocytoma). It is clinically similar to a raised fibrosarcoma, with a raised round tumor. This tumor is a highly pleomorphic, highly cellular tumor. Some of these cells have obvious vacuolization due to the storage of lipids, and mitosis is common. Some are atypical. Cells were positive for Vimentin. The recurrence rate after surgical resection was 25%, metastasis occurred in 35%, and the survival rate was 50%. Chemotherapy can improve survival. ^[1]

Malignant histiocytoma

Malignant fibrohistiocytoma, also known as malignant histiocytoma, is the most common

Malignant histiocytoma is not uncommon. Occurs most often in men and is more common in adults and the elderly.

The cause is unknown.

The pathogenesis is unclear.

According to clinical manifestations, skin lesion characteristics, and histopathological characteristics can be diagnosed.

In imaging, malignant histiocytoma must be distinguished from fibrosarcoma, osteolytic osteosarcoma, lymphoma, and osteolytic bone metastases. Histologically, it must be distinguished from fibrosarcoma (spinous cells, herring bone-like structure) and osteosarcoma (tumorous osteogenesis). Similar malignant histiocytoma areas seen in fibrosarcoma and osteosarcoma should be further studied. the study. In cases where the diagnosis of malignant histiocytoma is uncertain or uncertain, the diagnosis must be based on a sufficient and large number of histological sections. In addition, the histological differential diagnosis of malignant histiocytoma also includes bone metastasis of cancer. Their longer cells are arranged in a fuzzy lamellar structure, while the cells of malignant histiocytoma can also have an epithelial appearance and can aggregate into Groups of vesicles.

Malignant histiocytoma can be multiple on the bone and tends to recur locally even after extensive resection. Preoperative chemotherapy is the same as that used for osteosarcoma, and almost half of the cases can produce good results. The postoperative chemotherapy regimen is the same as that used for osteosarcoma, which can significantly improve the survival rate. Therefore, the treatment of malignant histiocytoma is similar to osteosarcoma. It is particularly emphasized that the scope of malignant histiocytoma resection must be extensive or radical, even beyond the scope of osteosarcoma resection. Mohs microsurgical resection with less recurrence.

The prognosis of malignant histiocytoma is related to the site of occurrence, and the prognosis is deeper in the tumor and in the proximal end of the limb. Tumors that occur on the basis of radiation dermatitis have a particularly poor prognosis. The recurrence rate after surgical resection was 25%, metastasis occurred in 35%, and the survival rate was 50%.

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