What Is Adrenomyeloneuropathy?

Adrenal cortisol-associated mental disorders and adrenal insufficiency associated with mental disorders are both mental disorders associated with adrenal cortical dysfunction. Cortisolism, also known as Cushing's syndrome, is associated with mental disorders that are caused by hyperadrenocortical function and excessive cortisol secretion. Adrenergic hypofunction, also known as Addison's disease. The accompanying mental disorders are mainly mental disorders and neurological symptoms caused by insufficient adrenal hormone secretion.

Adrenal cortisol-associated mental disorders and adrenal insufficiency associated with mental disorders are both mental disorders associated with adrenal cortical dysfunction. Cortisolism, also known as Cushing's syndrome, is associated with mental disorders that are caused by hyperadrenocortical function and excessive cortisol secretion. Adrenergic hypofunction, also known as Addison's disease. The accompanying mental disorders are mainly mental disorders and neurological symptoms caused by insufficient adrenal hormone secretion.

Causes of mental disorders associated with adrenal dysfunction

In general, the etiology of mental disorders associated with adrenal cortical dysfunction is unclear.

Various doctrines

The main mental disorder associated with hyperadrenocorticalism is increased corticosteroid secretion. Such as Cushing's syndrome due to long-term excessive secretion of cortisol, as well as primary adrenal tumors excessive secretion of cortisol, pituitary or non-pituitary ACTH caused by excessive secretion.

(1) The theory of excessive adrenaline secretion Depressive disease and adrenocorticotropic disease have similar susceptibility. The occurrence of mental disorders is caused by alkalosis, hypertension, etc. due to the decrease of blood potassium and blood chlorine when adrenaline is hyperactive. Caused.

(2) Neurotransmitter theory The pituitary-adrenergic system and catecholamine metabolism have an internal connection. Endocrine disorders can lead to depression, and depression can cause endocrine disorders. Both are causal.

(3) Genetic factors and personality traits may also be related to the occurrence of mental disorders.

2. Adrenal cortex with mental disorders

(1) It is believed to be related to factors such as trauma, surgery, pregnancy and other bleeding, thrombosis, arteritis, fungal infection, and metastases.

(2) Autoimmune factors Atrophy of the adrenal glands due to immune deficiency. So some people think it is an immune disease.

(3) Factors of tuberculosis infection Adrenal hypofunction is also considered to be one of the main reasons.

Clinical manifestations of mental disorders associated with adrenal cortical dysfunction

1. Adrenal cortisol-associated mental disorders

(1) Mental disorders Depressive state About 60% to 80% have depressive symptoms of different degrees, similar to endogenous depression, but also show anxiety depression and delusional depression. Personality changes are mainly based on persistent emotional instability, irritability, irritability, sadness or crying. Hallucinations are mostly hallucinations, hallucinations and illusions. Dementia is often poor in memory and difficult to understand, similar to the performance of cerebral arteriosclerotic dementia and senile dementia. disorders of consciousness Some of them show drowsiness.

(2) Neurological symptoms: Extremity muscle weakness or atrophic tremor, seizures. Weakness or atrophy of limb muscles, tremors and spasms

2. Adrenal cortex with mental disorders

(1) Mental disorders Personality changes In the early stages of illness, emotional instability, irritability or crying, and negativeness are common. Manic or depressive state Manic state is characterized by euphoria, etc., but associated with Ben Yi, increased speech and no psychomotor excitement; Depressed state is characterized by dullness, sadness, sadness, etc., but no association delay, mental movement Sexual inhibition. hallucinations or delusions occur in multiple cycles. Endocrine Psychiatric Syndrome , that is, decreased desire, emotional agitation, irritability, loss of appetite, irregular menstruation, etc. State of dementia A few cases may be manifested mainly by mental retardation. Some people point to generalized dementia. Disorder of consciousness From delirium to coma from drowsiness and drowsiness, some of them occur suddenly, mostly in adrenal crisis.

(2) Neurological symptoms , diplopia, seizures, dizziness, syncope, and headache.

Adrenal cortical dysfunction with mental disorders

Consistent with laboratory changes of the primary disease (hyperadrenal hyperfunction, decline).

The changes of EEG during adrenal insufficiency mainly include slowing of alpha rhythm and decreasing amplitude, and there are changes in diffuse theta frontal dominance wave and rhythmic high amplitude fast wave. This general slow-wave EEG is similar to EEG changes of hypoglycemic hepatic encephalopathy and cerebral hypoxia, and belongs to the general EEG waveform with reduced metabolic activity of the central nervous system.

Diagnosis of mental disorders associated with adrenal cortical dysfunction

1. There is evidence of adrenocortical lesions.

2. There are symptoms, signs and laboratory examination basis of adrenal cortical dysfunction.

3. Mental symptoms change with the development of physical symptoms.

4. It should be distinguished from other endocrine dysfunction associated with mental disorders and other functional mental illnesses such as schizophrenia, hysteria and depression.

Adrenal cortical dysfunction associated with mental disorders

1. Adrenal cortisol-associated mental disorders

(1) Feasible radiation, surgery and chemotherapy.

(2) Treatment of mental disorders For symptomatic treatment, antidepressants such as imipramine and amitriptyline fluoxetine (Baiyoujie) can be used. Diazepam (anazepine) and hydroxyzine (antelol) can also be used.

2. Adrenal cortex with mental disorders

(1) Hormonal therapy Adrenal corticosteroid replacement therapy is available. It is effective for both mental disorders and physical diseases, but this disease is likely to cause the occurrence of hormonal psychiatric disorders after steroid overdose, so it is necessary to prevent overdose. Do not cause hormonal psychiatric disorders.

(2) Treatment of mental disorders. Anxiolytics or antidepressants can be used. Antipsychotics should be used with caution, because they can easily induce hypotensive prolapse.