What Is Central Obesity?
Congenital obese people have a slower substance metabolism and the rate of substance synthesis is faster than the rate of decomposition.
Congenital obesity
discuss
- Chinese name
- Congenital obesity
- Foreign name
- Congenital obesity
- Congenital obese people have a slower substance metabolism and the rate of substance synthesis is faster than the rate of decomposition.
- 5 causes of congenital obesity 2010-7-4 39 Health Network introduced five internal causes of obesity:
1. Genetic factors The onset of simple obesity in humans has a certain genetic background. Mayer et al. Reported that one of the parents was obese and their children's obesity rate was about 50%; both parents were obese and their children's obesity rate rose to 80%.
Human obesity is generally considered to be a multi-gene heredity, and heredity plays a prone role in its pathogenesis. The formation of obesity is still related to the interaction of lifestyle behaviors, feeding behaviors, hobbies, insulin response, and socio-psychological factors.
2. Neuropsychiatric factors It is known that two pairs of neural nuclei related to feeding behavior exist in the hypothalamus of humans and various animals. One pair is the ventrolateral nucleus (VMH), also known as the satiety center; the other pair is the ventrolateral nucleus (LHA), also known as the hunger center. When the satiety center is excited, it feels full and refuses to eat, and when it is destroyed, the appetite greatly increases; when the hungry center is excited, it has a strong appetite, and when it is damaged, it is anorexia and refuses to eat.
The two regulate each other and restrict each other. They are in a state of dynamic equilibrium under physiological conditions, so that the appetite is adjusted to the normal range and the normal weight is maintained. When a lesion occurs in the hypothalamus, regardless of the sequelae of inflammation (such as meningitis, post-encephalitis), trauma, tumors, and other pathological changes, such as the destruction of the medial ventral nucleus, the function of the ventral lateral nucleus is relatively high and gluttony is insatiable. obesity.
Conversely, when the ventrolateral nucleus is destroyed, the ventrolateral nucleus function is relatively high and anorexia is caused, causing weight loss. In addition, this area has close anatomical links with higher-level neural tissues, which can also regulate the feeding center to a certain extent. The blood-brain barrier at the hypothalamus is relatively weak. This anatomical feature makes it easy for many biologically active factors in the blood to migrate there, thereby affecting feeding behavior.
These factors include: glucose, free fatty acids, norepinephrine, dopamine, serotonin, insulin, and the like. In addition, mental factors often affect appetite, and the function of the center of the bait is restricted by the mental state. When the sympathetic nerve is excited or the adrenergic nerve is stimulated (especially the receptor is dominant), the appetite is suppressed; when the vagus nerve is excited When insulin secretion increases, appetite is often hyperactive. The ventromedial nucleus is the sympathetic nerve center, and the ventrolateral nucleus is the parasympathetic nerve center. Both play an important role in the pathogenesis of the disease.
3. Hyperinsulinemia In recent years, the role of hyperinsulinemia in obesity has been remarkable. Obesity often coexists with hyperinsulinemia, but it is generally believed that hyperinsulinemia causes obesity. Hyperinsulinemia obese people release about three times the amount of insulin.
Insulin has a significant role in promoting fat accumulation. Some people believe that insulin can be used as an indicator of overall fat mass and can be used as a monitoring factor for obesity in a certain sense. Some people think that the plasma insulin concentration is significantly positively correlated with the total lipid.
4. Abnormal brown adipose tissue Brown adipose tissue is a type of adipose tissue that has only been discovered in recent years, and corresponds to white adipose tissue mainly distributed under the skin and around the internal organs. The distribution of brown adipose tissue is limited, only in the interscapular region, the back of the neck, the axillary region, the mediastinum, and around the kidney. The appearance of the tissue is light brown, and the changes in cell volume are relatively small.
White adipose tissue is a form of energy storage. The body stores excess energy in the form of neutral fat. When the body needs energy, the neutral fat in the fat cells is used for hydrolysis. The volume of white adipocytes varies greatly with energy release and energy storage.