What is chronic granulomatous disease?
Chronic granulomatous disease is a potentially fatal genetic disorder that affects the body's ability to fight bacterial and fungal infections. Specialized white blood cells called phagocytes lack an important enzyme that is needed to disintegrate and destroy pathogens. As a result, infants and disorders often suffer from frequent attacks of pneumonia, digestive problems and skin infections. Treatment usually includes daily antibiotics in the fight against existing infections and prevents new ones from being created. There is no clear remedy for chronic granulomatous disease, but bone marrow transplantation has proved to be effective in restoring healthy phagocytes and strengthening the functioning of the immune system in many patients.
When healthy phagocytes confront bacteria or fungi, they basically enjoy pathogens and decompose them using superoxide anions. In the case of chronic granulomatous disease, the enzyme is needed to release anions either absent or defective. Phagocytes are made unnecessary and inFekni bacteria and mushrooms. Medical research has shown that chronic granulomatous diseases are the result of genetic defects on X -linked chromosomes. Males are much more likely to develop than women, and the first symptoms are likely to arise in childhood or very early childhood.
A child with chronic granulomatous disease is highly sensitive to a number of different infections, especially those that affect the lungs, skin and gastrointestinal tract. Bacterial pneumonia is one of the most common types of recurring infections, although other chronic respiratory diseases may occur. Frequent diarrhea, nausea and vomiting may occur as well as swelling of chronic lymph nodes in the weakness and neck. Abscesses can develop in the rectum, lungs, liver or spleen that have bacteria and cause recurring problems.
Blood tests are the most eportive means to DIgnostics of chronic granulomatous disease. Specialists can check samples for abnormal phagocytic enzymes and other narratives factors. The doctor may also collect tissue samples and take X -rays to see if the internal organs were seriously damaged by recurrent infections.
patients who have active pneumonia or other types of infections are immediately administered by intravenous or oral antibiotics. The child may need to stay in the hospital for several days or weeks so that doctors can monitor the effectiveness of medical therapy. Prophylactic antibiotics and antifungals are commonly prescribed to help prevent future infections. If the symptoms of a person are serious and do not solve, despite medical care, bone marrow transplantation may be planned. The outlook of each patient is different, but careful monitoring and supportive treatment allow many people to survive into adulthood.