What is the lack of factor VIII?

Lack of factor VIII is a blood disorder characterized by insufficient or poorly functioning factor VIII, one of the factors of blood clotting, also known as an anti-hamophilic factor (AHF). The lack of factor VIII is the cause of haemophilia and, a disease in which blood does not spark well after injury, causing symptoms such as serious bleeding and frequent bruises. Factor VIII is expressed by the F8 gene on chromosome X and is a recessive feature of the X -bound X. It affects only men or women who inherit the defective gene F8 from both parents. Women are more often asymptomatic carriers of genetic defects.

Factor VIII is the most common cause of haemophilia. The result is the formation of blood clots with insufficient amounts of protein fibrin, leading to weak and slow shaped clotting. About one of every 5,000 men suffers from a lack of factor VIII and 30% does not have a family history, suggesting recently mutated genes. Different types of mutations in F8 lead to different types of factor deficiency VIII and haemophilia and withThey differ in severity depending on how much the VIII factor is present in the patient.

Symptoms of factor VIII include internal and external episodes of bleeding, especially after trauma. Patients with more serious forms of the disease may experience excessive bleeding due to less injury. Joint bleeding can lead to chronic symptoms including pain, impaired movement and even disfigurement. Hemophilia A is often diagnosed at the beginning of life, for example, when a newborn develops serious bruises or inter -regional bleeding due to the delivery of pliers or the supply of vacuum. The first manifestation of the disease may also be excessive bleeding during a routine blood test or circumcision.

haemophilia and is treated with intravenous transfusions of factor VIII, either as needed or as a preventive measure depending on the severity of the disease and the patient's specific needs. Disease can also be treated with desmopressinEM, which releases factor VIII stored in the walls of the patient's blood vessels. In some cases, the patient develops inhibitory antibodies against factor VIII supplied through transfusions. Factor VII transfusions are sometimes useful in such cases.