What is hypergamaglobulinemia?

Hypergammaglobulinemia is a rare, hereditary health in which the patient has an abnormally high level of gamma globulin. Gamma Globulin is a class of proteins found exclusively in the blood and primarily concerns antibodies. In other words, a patient with hypergammaglobulinemia has too many antibodies floating around his blood. together with anemia; poor immunity; and susceptibility to bacterial and opportunistic infections. With these symptoms, the disease is an immunoproliferative disorder, which means that it strongly weakens the immune system. When the immune system is affected, it causes a person much less able to avert infections. In addition, it can even do small infections such as normal colds, feel much worse. Virus odoficiency 1 (HIV-1), rheumatoid disease, poems and liver cirrhosis. The treatment of the disease generally includes intravenously feeding of immunoglobulin or the use of antibiotics. Many patients, despite treatment, have to live with a weakened immune system for the rest of their lives. The most common type that lIdé experience, is an excess of immunogloblin known as IgM. Other types are characterized by the lack of the main immunoglobulins Iga, IgE and IgG.

The first and primary type is called Hyper IgM type 1 and this is the one with elevated levels of gamma globulin. The second is the mutation of the deaminasea (AICDA) gene induced by activated activated in the short arm of the chromosome 12. The third type is also a mutation located on the surface of antibody B Bells. Hyper IgM Type 4 is similar to the first type, but the exact cause must still be determined. Hyper IgM Type 5 is a mutation of the Uracil Glykosylasea (UNG) DNA (UNG), which also on Chromosome 12.

Waldenstrom's macroglobulinemia is a malignant variation of immunoproliferative immunoglobulin disorders, a category in which hypergammaglobulinemia decreases, even if it is not considered a form of hypergammaglobulinemia. This condition generally affects people when they are around 55 years of age, with a slight overLibra to men. Patients who develop this disorder usually live for about six years. It is a relatively rare disorder that in the United States annually with about 1,500 cases; There are about 10.3 annual incidents for every 1 million people in the UK.