What is hyperhomocysteinemia?
Hyperhomocysteinemia is a health condition in which the total homocysteine concentration in plasma is abnormally increased. This disorder is associated with several vascular, neurological and skeletal problems, including stroke, heart attack, clotting, mental retardation, eye abnormalities and osteoporosis, among many other complications. Hyperhomocysteinemia may be due to the presence of one or two inherited mutated genes that cause homocysteine breaking failure, a naturally occurring chemical in the body. Increased homocysteine may also occur due to excessive exercise, too low folate diet, vitamin B6 or vitamin B12, kidney disease or in response to medicines.
Hyperhomocysteinemia increases the risk of precipitation or thrombosis and leads to various serious complications such as stroke or heart attack. Homocysteine is usually produced in the body for various necessary functions in cells, but should be quickly distributed enzymes quickly. Enzyme are proteins in the body that have withCopiness to respond and cut other chemicals. Enzymes involved in the decomposition of homocysteine are called and methionine synthase (MS), methylenetetrahydropholate reductase (MTHFR) and cysthionin beta-synthase (CBS).
Methionine synthase needs vitamin B12, vitamin found in animal products to perform its functions, so that diet and other disorders that affect B12 can lead to MS form hyperhomocystenemia. Similarly, if MTHFR or CBS cannot be created, this can also lead to increased homocysteine in the blood. However, some people are born with mutated genes that prevent the CBS and MTHFR enzymes from creating correctly.
A rare CBS -affected disorder is called homocystinuria or CBS deficiency. This disorder often shows no symptoms at birth, although almost a quarter of all those with lack of CBS die at the age of thirty. Symptoms include seizures, mental retardation, top building, knOck-rails, eye abnormalities, precipitation, homocysteine in urine and arterial hardening. This disease is caused by a recessive gene, so a person must get the gene from both parents to develop fully developed disorders. But someone with one gene may experience mild symptoms.
A person with one gene mutation may also suffer from a slight increase in homocysteine, but a person with two mutations or homozygous mutations develops much more difficult hyperhomocystymia. The manifestations of this disorder are similar to CBS deficiency and include stroke, heart attack and other thrombotic complications at usually early age, long bones, eye abnormalities, mental retardation, seizures, oily liver and osteoporosis. Some also proposed the relationship between Alzheimer and Hyperhomocysteinemia.
Treatment of hyperhomocysteinemia includes vitamin supplements, low in protein and anticoagulants. These treatments are not always effective, but in some cases it can help prolong the life of someone with a deep increased homocysteine. PRThe change of diet can be quite effective about those who have more situational climb in homocysteine.