What is osmotic diuresis?
Osmotic diuresis, or dissolved diuresis, refers to increased urination accompanied by everyday excretion of dissolution of more than 750 million. Increasing the filtration of soluts that could not be reabsorbed by kidneys such as urea or glucose can lead to impaired reabsorption of sodium and water. This leads to osmotic diuresis. The osmotic diuresis leads to a loss of water from the renal system, so it can cause hypovolemia or abnormally low blood volume. It may occur in patients using pharmacological diuretics or in patients who have poorly controlled diabetes mellitus. It is an important concept in nephrology, especially because it can be used to reduce blood volume in hypervolemic conditions such as hypertension and swelling. In osmotic diuresis, substances that are not easily reabsorbed by renal tubules are maintained in lumen, causing an increase in osmotic pressure. With the phenomenon of osmosis, where water passes through a semipermeable membrane into a solution of high concentration of solut, waterThen he goes to the lumen. This leads to a reduction in water reabsorption, resulting in increased urine performance.
osmotic diuretics are substances that are not easily reabsorbed by renal tubules. These substances include urea, sucrose and mannitol. Mannitol mainly affects the proximal tubules and inhibits the water and solut of reabsorption in the kidney tubules by increasing the osmolarity of the renal tubular fluid. It is used in health conditions in which the amount of body fluids such as hypertension, brain edema, kidney failure and glaucoma increases. Sometimes it is used to treat overdose by aspirin, bromides and barbiturates.
disease conditions associated with kidney failure reabsorb excess soluts from tubular fluid in osmotic diuresis. For example, in diabetes mellitus, blood glucose concentration levels become abnormally increased. When a blood glucose concentration reaches about 250 milligrams per decisionLiter, tubuly is only a very small amount of glucose. At this point, the "maximum transport" of tubules is exceeded.
Increased glucose burden in the kidneys exceeds the capacity of tubules on reabsorbu glucose. Excess glucose in tubules serves as an osmotic diuretic, leading to rapid loss of fluid and frequent urination or polyuria. Polyuria diabetes is accompanied by polydipsia or increased drinking frequency. Polydipsia occurs due to high urine detection and activation of the thirsty mechanism.