What is Spinocerebellar Ataxia?

Spinal cerebellar ataxia is the main type of hereditary ataxia. Its common features are middle-aged onset, autosomal dominant inheritance, and ataxia. In addition to cerebellar ataxia, clinical manifestations may be accompanied by ocular dyskinesia, slow eye movement, optic nerve atrophy, retinal pigment degeneration, pyramidal tract sign, extrapyramidal sign, muscle atrophy, peripheral neuropathy, and dementia.

Basic Information

English name
Spinocerebellar Ataxias
Visiting department
Neurology
Multiple groups
Middle-aged
Common causes
Heredity
Common symptoms
Unstable steps and shaking of limbs in the early stage; vague pronunciation in the middle stage, irregular eyeball rotation, and increased muscle discomfort; late stage speech is extremely unclear and cannot stand

Causes of spinocerebellar ataxia

Gene exon CAG copy number abnormal amplification caused by polyglutamine.

Clinical manifestations of spinal cerebellar ataxia

Initial stage
Unsteady walking while walking, limbs shaking. Slow response and poor accuracy.
Mid-term
When speaking, the pronunciation is ambiguous and the tone cannot be controlled. Eyeball rotation is not smooth, and the image is prone to "overlap". Muscle discomfort worsens, preventing writing. Sometimes I have difficulty swallowing and I easily cough when eating.
3. Late
Speaking is extremely unclear and even impossible to speak. Limb weakness, can not stand, need to use a wheelchair to move. Comprehension gradually declines, and finally loses consciousness and becomes lethargic.

Spinal cerebellar ataxia

1. Clinical examination of the cerebral nervous system.
2. Magnetic resonance (MRI) examination.
3. Genetic testing.

Diagnosis of spinal cerebellar ataxia

According to the procedures of the clinical examination of the cerebral nervous system to determine whether the patient has a cerebellar and spinal neurological disorder, he will then ask his family history (including his late relatives), and determine whether the patient is suffering from magnetic resonance (MRI) and genetic tests. Upper cerebellar atrophy.

Spinocerebellar ataxia treatment

This disease is a degenerative disease. At present, there are no medicines that can cure the disease. The emphasis is on rehabilitation treatments to enable patients to maintain the highest self-care ability as possible. It can also be treated with stem cells. After treatment, patients can recover their self-care ability, mobility ability, language ability, writing ability, etc. Levodopa relieves symptoms of tonicity and Parkinson's disease, chloroaniline butanoic acid reduces spasm, and amantadine improves ataxia.

Prognosis of spinal cerebellar ataxia

Although there is no medicine to treat this disease, if you can pay attention to the maintenance of your body, pay attention to diet, daily living, exercise regularly, cooperate with the rehabilitation training required for cerebellar atrophy, and keep practicing, it will help delay the deterioration of the disease.

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