What is systemic amyloidosis?
Systemic amyloidosis is a serious condition defined by augmented accumulation of amyloid deposits throughout the body. Systemic amyloidosis, associated with the presence of anomalous antibodies produced in the bone marrow, may endanger the function of organs contributing to organs. Treatment generally involves the use of drugs designed to inhibit antibodies production and alleviate inflammation and transplantation of the bone marrow. There is no drug for systemic amyloidosis. Biopsy, which is often obtained under local anesthetics, leather or bone marrow, usually shows increased amyloid proteins. Urine and blood analysis can also be carried out as a preventive measure to exclude the presence of other conditions that may mimic amyloidosis. Naturally, bone marrow produces versatile antibodies, has d up to fight against foreign pathogens that are re -adopted as soon as the threat is excluded. In the case of amyloidosis, the antibodies produced are mutated and cannot be metabolized or divided. With nowhere elseto move the antibodies through the body through the blood beet and turn into amyloid protein before settling in soft tissues.
extensive accumulation of amyloids may disrupt the functions of the system and organs, especially if nervous, respiratory and digestive systems are affected. Because systemic amyloidosis affects several soft tissues simultaneously, individuals experience different symptoms and symptoms. Individuals can easily get tired and experience discomfort, including insensitivity and swelling in their limbs. When the digestive system is affected, individuals develop reduced appetite, irregular bowel movements and unintended loss weight. Other symptoms may include arrhythmia, reduced kidney function and difficulty breathing.
In the absence of treatment, the treatment of systemic amyloidosis focuses on the treatment of symptoms. Combination of drugs, including steroid drugs such as dexamethasone, is generally given to alleviate inflammation and do not rejoiceof the groups. If amylulation of amyloids significantly worsens the function of organs, organs fail. Complications such as respiratory and kidney failure are not unusual and may require further extensive treatment to slow down the progression of symptoms.
In some cases, blood stem cells can also be made, usually harvested from their own stem cells and bone marrow transplantation. Transplantation makes it possible to replenish healthy antibodies to replace mutated, patients and inhibit the production of new anomalous amyloids. Stem cell transplantation brings a significant risk of complications and is not suitable for everyone.