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Direct current drug electrophoresis (Electrophoresis) A method of using direct current to introduce drug ions through the skin, mucous membranes or wounds into the body for treatment. In the drug solution, a part of the drug is dissociated into ions. Under the action of direct current, anions and cations are directed to move. If the cathode pad contains negatively charged drug ions or the anode pad contains positively charged drug ions, it will move towards the human body and enter the body.

Direct current drug iontophoresis

Direct current drug electrophoresis (Electrophoresis) A method of using direct current to introduce drug ions through the skin, mucous membranes or wounds into the body for treatment. In the drug solution, a part of the drug is dissociated into ions. Under the action of direct current, anions and cations are directed to move. If the cathode pad contains negatively charged drug ions or the anode pad contains positively charged drug ions, it will move towards the human body and enter the body.

In drug solution, part

(1) Introduced into the body is a large number of non-therapeutic solvents and matrices that do not enter the body.

(2) The drug can be directly introduced into the superficial lesions, and the concentration is higher in the local superficial tissues, and the action time is longer. The amount of the drug introduced by direct current is very small, and the concentration is very low for the whole body; but for local superficial tissues, the concentration is higher than other methods. E.g,

1. Basic theory of drug introduction:

Direct current iontophoresis is based on the principle of repulsion of the same sex charge and attraction of the opposite sex charge in the direct current electric field, so that drug ions are introduced into the human body through the intact skin or mucous membrane. Many experimental clinical observations have proven that under direct current, ions with different charges can be introduced into the human body. Cations are introduced from the anode, while anions are introduced into the body from the cathode.

2. Distribution and retention time of drug introduction:

The surface of human skin has a large number of pores, openings of the skin glands and sweat ducts. The main channel of drug ions into the body through direct current is the drainage hole of the sweat duct of the skin. An ion stack is formed in the skin. After a part of the drug ions enter the skin through the sweat gland orifice, they stay on the skin for a long time, forming a so-called "skin ion stack", and then gradually enter the bloodstream. Different types of drug ions stay in the skin for different periods of time, as short as several hours and as long as tens of days. For example, after neomycin is introduced into the body by direct current, it can remain in the local skin for 3 to 6 hours, streptomycin for 6 to 12 hours, and penicillin for 6 to 24 hours. Iodine is 15 to 20 days, and adrenaline can also accumulate in local skin layers for up to 20 days.

After some drugs are ionically introduced into the body, they can selectively stay in the organs that have affinity for the drug. For example, most iodine ions remain in the thyroid gland after being introduced into the body by direct current. Phosphorus is mainly accumulated in the central nervous system and bones.

3. Concentration of medicinal solution introduced into the body:

It is related to various factors such as current intensity, energization time, and parasitic ions.

The experiment proves that when the concentration of some commonly used solutions is below 5%, the introduction amount increases with the increase of the concentration; when the concentration is more than 5%, the introduction amount of the drug hardly increases. The amount of drug introduced into the body is proportional to the strength of the current and the time of energization within a certain range. However, when the current intensity increases to a certain value and the energization time exceeds 30 minutes, the amount of drug introduction does not increase accordingly.

4. The most commonly used drug iontophoresis therapy is the GZ-IIIC drug introduction hyperthermia, which uses low frequency modulation of intermediate frequency pulse current and drug guidance to combine intermediate frequency electricity and drug introduction to achieve the therapeutic effect on disease , Clinically proven to have exact efficacy. It is suitable for various bone hyperplasia and bone spurs and synovial hypertrophy formed on the edge of joints. Clinical use has proven to be effective for other swelling and pain and muscle soft tissue damage (periarthritis of shoulder, lumbar muscle strain, contusion). Easy to understand, safe to use, and easy to carry, especially suitable for clinic and home use.

Indication

Neuritis,

Direct current drug iontophoresis , referred to as drug iontophoresis, is a special method of direct current electrotherapy. The method of directing drug ions through the skin into the human body to treat diseases is called the "direct current drug iontophoresis method".

The basic principle of the direct current drug iontophoresis method is to use positive and negative electrodes to form a DC electric field outside the human body, add drugs with anions and cations to the DC electric field, and use the principle of "same sex repulsion and opposite sex attraction" to make drugs The cations are introduced into the body from the anode and the anions from the cathode to achieve the purpose of treating diseases. For example, the introduction of potassium chloride (potassium ions are cations) can improve the excitability of neuromuscular muscles and is used to treat peripheral neuritis and neural paralysis. For another example, the introduction of Chinese herbal medicine Caowu (the main component is alkaloids, containing cations) can treat joint pain and nerve pain caused by bone hyperplasia. The most commonly used method for treating bone hyperplasia is to use edible vinegar (the main component of edible vinegar is acetic acid, which contains anions) as the introduced drug. Acetate ions enter the body through the skin under the action of the electric field and interact with the calcium ions on the bone to reduce the deposition of calcium salts, reduce inflammation and relieve pain, and achieve the purpose of treating bone hyperplasia.

The main characteristics of direct current drug iontophoresis for bone hyperplasia

(1) Directly introduce the drug into the local tissue, so that the concentration of the drug in the local tissue is significantly increased, and the treatment of bone hyperplasia or "bone spur" in the joints of the extremities is better. Because there is less soft tissue around the joints of the extremities, the lesion is shallower than the body surface, and the ion of the drug is easy to reach.

(2) The drug takes a long time. Drugs introduced by direct current form a local "ion stack" and then gradually enter the body. Therefore, the drug stays in the body longer than other methods of administration, and the action time is longer. Because bone hyperplasia is a chronic development process and the treatment time is relatively long, direct current drug iontophoresis is beneficial to the treatment of bone hyperplasia.

(3) Direct current drug iontophoresis is administered from outside the body, avoiding side effects or toxic side effects caused by oral or injectable drugs. For example, oral drugs can cause gastrointestinal irritation; injections can easily cause infections, bleeding, and pain. At the same time, the direct current drug iontophoresis does not damage the skin, does not cause pain, and is easy to operate and easy for patients to accept.

(4) In the case of direct current drug introduction therapy, in addition to the direct action of the direct current electric field and the drug on the local tissue, it also acts on the whole body tissue through the principles of nerve reflex. It has the characteristics of combining local treatment and whole body treatment.

What are the indications and contraindications for DC electrotherapy?

"Indication" refers to patients with certain diseases or clinical manifestations for which a treatment method is applicable? And "contraindications" refer to patients with certain diseases or clinical manifestations forbidden to use a certain treatment method? In the application of DC electrotherapy for physical therapy, the indications and contraindications should be well grasped.

Direct current therapy and direct current drug iontophoresis can be used for the treatment and prevention of numbness, pain and radiation pain in the neck, shoulders, upper limbs and adjacent tissues caused by osteogenesis. It has a good therapeutic effect on neurostimulation, muscle weakness, muscle atrophy, joint dysfunction and decreased limb sensory function caused by osteogenesis. Patients can choose DC electric physiotherapy equipment for DC electric therapy under the guidance and advice of the physician according to their actual situation.

The contraindications of direct current therapy are: patients with malignant tumors; patients with malignant hematological diseases; patients with acute eczema on the skin; patients with important organ diseases; patients with allergies to direct current; patients with insensitivity or lack of sensation due to limb nerve damage and presets Patients with severe skin disease or skin damage on the metal electrode plate. The main reasons for the prohibition of direct current physiotherapy for the above patients are to prevent the disease from worsening on the one hand and to prevent skin infections or burns on the other.