What factors lead to cisplatin resistance?

cisplatin is a medicine administered to people with certain forms of cancer in the framework of the treatment of chemotherapy treatment organized and provided by the doctor. The human body can develop resistance to cisplatin, because factors, including targeted cells that become immune to drug components and various molecules in a cell rejecting cisplatin before having the opportunity to work effectively. Cisplatin attempts to damage DNA in cancer cells; Naturally, the body attempts to repair damaged DNA proteins, so some cells repair damage caused by cisplatin, reducing the effectiveness of the drug. The colorless liquid is usually served directly into the vein in the hand, arm or collarbones in long sessions for up to eight hours for months. Cancer cells, including cells that cause testicular, lungs and bladder, are focused on cisplatin in an effort to kill cells and stop the spread of the disease through the body.

one factor enabling developmentJem cisplatins is the ability of the cell to change its properties and create a defense that does not allow the drug to penetrate and act in it. The reasons for drug failure to penetrate cancer cells, a process known as reduced intracellular accumulation, scientists are not known. One theory suggests that the cancer cell is necessary to actively help pass the cisplatin through its outside and after long -term use can stop this help and the drug move around the bloodstream without being absorbed.

To work efficiently, cisplatin works directly on DNA cancer cells to destroy it from the inside. There are more molecules in the cell than just DNA, which can interact and exclude the drug to increase Chance there is resistance to cisplatin. Detoxifying molecules in the body cells help maintain good health and exclude pollutants. The metalothionein detoxifier excludes heavy metal from the inner cells and believes that it attracts cisplatin. After attraction of the molecule, the cisplatin is expelled from the cancer cell before it hasthe importance of damaging DNA.

It is assumed that some proteins help DNA in the cell in repairing itself after exposure to chemotherapeutic drugs. Cisplatin resistance can occur when these proteins are present in a drug -aiming cell. Protein levels such as XPE-BF nuclear protein often grow after administering chemotherapeutic drugs for a long time, increasing the likelihood of cisplatin resistance.