What Are Polymyxins?

Polymyxin (polymyxin) is a group of polypeptide antibiotics produced by Paenibacillus polymyxa. Inhibits most Gram-negative bacteria. Dissolve in water, methanol and hexane under acidic conditions. Applicable to some Gram-negative bacteria such as E. coli, pneumoniae, and Pseudomonas aeruginosa. Clinical trends are eliminated.
Polymyxin

Polymyxin (polymyxin) is a group of polypeptide antibiotics produced by Paenibacillus polymyxa. Inhibits most Gram-negative bacteria. Dissolve in water, methanol and hexane under acidic conditions. Applicable to some Gram-negative bacteria such as E. coli, pneumoniae, and Pseudomonas aeruginosa. Clinical trends are eliminated.

Chinese name

Polymyxin

Foreign name

polymyxin

Types of

Peptide antibiotics

Alias

Keli Maixian

Polymyxin synonym

Colimex, polymyxin E, colistin and so on.

Polymyxin main ingredients

Polymyxin sulfate.

Polymyxin pharmacological action

It has antibacterial effect on Pseudomonas aeruginosa, E. coli, Klebsiella pneumoniae, and gram-negative bacteria such as Haemophilus, Enterobacter, Salmonella, Shigella, Pertussis, Pasteurella and Vibrio. Proteus, Neisseria, Serratia, Pluviton, Gram-negative bacteria and obligate anaerobic bacteria are not sensitive to this class of drugs. Bacteria have cross-resistance to this product and polymyxin E, but no cross-resistance has been found between this class of drugs and other antibacterials.

Polymyxin indications

It is mainly used for wound, urinary tract, eye, ear, and trachea infections caused by Pseudomonas aeruginosa and other pseudomonas, and can also be used for sepsis and peritonitis.

Polymyxin adverse reactions

Rash, itching, drug fever, and loss of appetite, nausea, vomiting, and diarrhea can occur.

Polymyxin usage and dosage

Oral: 500,000 to 1 million units / time for adults, 3 to 4 times / day; children's dose halved, 3 to 4 times / day.

Polymyxin considerations

Damage to the kidney is more common, and those with renal insufficiency should be reduced.

It should not be used in combination with other drugs with nephrotoxicity or neuromuscular blockade to avoid accidents.

Polymyxin drug interactions

Sulfa drugs, TMP, rifampicin, and semi-synthetic penicillin can enhance the antibacterial effect of polymyxins on E. coli, Enterobacter, Pneumoniae, Pseudomonas aeruginosa and the like.

Polymyxin overdose

Induce vomiting and symptomatic treatment, plenty of water and fluids. Due to the large molecules of this product, it is difficult to eliminate it by hemodialysis.