What factors affect a sufficient dose of glucosamine?

glucosamine sulphate is a dietary supplement folkly, which is expected to reduce the symptoms of pain, stiffness and inflammation associated with osteoarthritis. While a number of multi -year, large populations, placebo -controlled studies have found a statistically significant improvement in arthritis symptoms in patients receiving glucosamine sulphate after six weeks of treatment, only a few studies have shown a significant level of improving patients treated with the most common form of supplement, glucosamine hydrochloride). Since the United States has not begun to assess the safety or efficacy of this supplement, the review of available scientific data on glucosamine has not found any significant degree of individual variability at an effective dose. There are no indications that adjustments to dosage of a typical daily dose of adults 1.5 g glucosamine sulphate are essential for accommodation of the patient's age, kidney health, liver function, appreciated or parsible pharmaceutical regime.

Although no interactions with a drug with glucos have been determinedAminem, some scientists theorized that the supplement has the potential to interact with doxorubicin, teniposide, etoposide, warfarin, sugar-reducing drugs to reduce blood levels, insulin and non-steroidal anti-inflammatory drugs. No such interactions were reported through these warnings. As a result of a reduction in the severity of pain and stiffness, some patients said that after a few weeks of a single daily 1.5 g of glucosamine they could reduce their use of non -steroidal anti -inflammatory drugs.

Some experts recommended the use of a daily dose of glucosamine up to 30 g per day, administered in divided doses. The use of 30 g glucosamine doses regularly, even in patients with severe arthritis, is generally considered to be excessive. The Results of the Study using twice the standard 1.5 g daily glucosamine doses did not detect a statistically significant improvementGastrointestinal side effects such as nausea and gas as well as headaches. Increasing the standard dose is not recommended.

There is no consensus in the scientific community regarding the mechanism of action by which glucosamine sulphate can help reduce the symptoms of arthritis. Despite the theoretical claims that the supplement can help prevent damage to connective tissue, there is little evidence to support these claims. Some scientists have suggested that the administration of a single glucosamine dose causes a small effect, cumulative doses can stimulate anti -inflammatory proteoglycan synthesis or cause chondrocytesis catabolic activity to protect articular chondrocytes and cellular radobors. Glucosamine can also stimulate hyaluronic acid product, which helps to reduce inflammation by increasing joint lubrication and inhibition of liposomal enzymes that are responsible for cartilage degradation. Since 2011, further research is necessary to determine whether and how glucosamine sulphate helps in symptomOmech arthritis.