What is takolimus?
Tacrolimus, or Fujimycin, is an immune -suppressed drug prescribed mainly after the transplantation of organs to reduce the risk of rejection of transplantation. Isolated from the Japanese soil sample containing streptomyces tsukubaensis, the name of the drug tacrolimus was derived from the phrase "immunosuppressants tsukuba macrolide". The drug, which was first approved by food and drug management (FDA) in 1994, was used for patients receiving liver, heart, pancreas, kidneys, lungs, small intestines, cornea, skin, bone marrow, trachea and limb transplantation. The drug works by inhibiting the production of the body interleukin-2, a chemical mediator involved in episodes and inflammation of acute rejection. Doctors also prescribe this medicine to treat inflammation associated with ulcerative colitis, autoimmune skin conditions and severe eye inflammation. The effect with the same volume of drug. Immunosuppression by this drug caused a lower level of rejection of transplants compared to cyclosporin - 30.7 percent compared to 46.4 percent -According to one clinical study. Results in patients with liver transplantation are better in tacrolim than in cyclosporin in the first year after transplantation. Takolimus is usually prescribed in a posttransplant cocktail with other medicines. Initial doses range from 0.15 milligrams to 0.20 milligrams per kilogram of body weight in daily infusion.
In the form of ointment, tacrolimus can be used to treat eczema. Its effect and efficiency are similar to the method of steroid. The advantage of this Steroid drug is that it does not cause skin atrophy. Therefore, it can be used continuously on even thinner areas of the skin of the face and lids. The ointment has ALSO was used to treat the Vitiligo segment, especially on the face.
The main side effects of drug use, which may be severe, include headache, heart damage, blurred vision, liver and kidney problems, seizures and diabetes. In addition, it is more difficult to manage mold andviral infections. The side effects occur both in both intravenous and oral administration of the drug and may require a reduction in the dose used. Increased blood glucose may require insulin administration. In patients taking tacrolimus, the ratio of more than one side effect is about 99.8 percent.
In patients who receive immunosuppressants to avoid rejection of transplants, malignancy is known. Pregnant or nursing mothers and infants should not take tacrolimus. Other contraindications for drugs include severe liver or kidney disease, active infections, cancer and acute heart disease. Patients must be careful when exposed to the sun due to the photographic effect of this drug. Grapefruit juice can also increase the effects of the drug.