What is tetrahydrobiopterin?

tetrahydrobiopterin is a naturally occurring nutrient that is essential in the human body. This is important as a capping in several enzymes needed for the correct mental function. The nine is also known as Thb, BH4 and Sapropterin. The function of tetrahydrobiopterin is to help in creating the necessary neurochemicals. Serotonin, adrenaline and nitric oxide (NO) are synthesized by enzymes that cannot be created without the presence of tetrahydrobiopterin.

its deficiency or limited production leads to lack of tetrahydrobiopterin. When a limited amount of substance is present in the human body, essential amino acid phenylalanine begins to build. This acid is obtained by food and is very common. In the body, phenylalanine is converted into phenylalanine hydroxylase (PAH), which is then produced by its interaction with tetrahydrobiopterin. Without sufficient tetrahydrobiopterin to interact with it, the PAH stock in the body will be maximized and phenylalanine will begin to build. Usually this condition is in a very smallAge and leads to problems with learning and disorders of motor function.

There is also a genetic disorder known as phenylketonuria (PKU), which shows similar symptoms. PKU causes the body to have difficulty producing PAH, which in turn means accumulation of phenylalanine. In addition, a limited amount of PAH means that there will be a limited amount of Tyrosin enzyme, which is formed when tetrahydrobiopterin is combined with PAH. This enzyme is essential in creating dopamine and norepinephrine, two basic neurotransmitters. The condition was discovered in 1934 by Norwegian physician Ivar Asbjorn Folling, known as Folling's disease . In the developed world, most children are projected on this condition aged six to 14 days, using a simple blood test.

A prescription drug known as Kuvan® was created by Biomarin Pharmaceutical Corporation for PKu treatment. In SPRunned States Food and Drug Administration (FDA) approved the sale of this drug on December 13, 2007. The proprietary process used to create this drug uses the salt form of tetrahydrobiopterin and has been proven in clinical trials to reduce the level of phenylalanine in the blood. When using treatment and strict diet, PKu can usually be controlled and its symptoms are controlled.