What Causes Weak Bones?

Ribomycin sulfate injection, suitable for the treatment of respiratory infections and urinary tract infections caused by E. coli, Proteus, Klebsiella pneumoniae, Haemophilus influenzae, Shigella , Biliary tract infections, etc.

Drug Name: Ribomycin Sulfate Injection

Drug type: prescription
Use classification: Antibiotics

Characteristics of Ribomycin Sulfate Injection

This product is colorless, slightly yellowish or yellow-green clear liquid.

Indications of Ribomycin Sulfate Injection

It is suitable for the treatment of respiratory tract infections, urinary tract infections, and biliary tract infections caused by E. coli, Proteus, Klebsiella pneumoniae, Haemophilus influenzae, and Shigella.

Ribomycin sulfate injection specifications

2ml: 0.5g (500,000 units)

Dosage and Administration of Ribomycin Sulfate Injection

Intramuscular injection. Adults: 0.5g ~ 0.75g (1 ~ 1.5 sticks) once a day, twice a day. Pediatric injection is divided into 2 injections of 20 to 40 mg / kg per day. The course of treatment is generally within 10 days and no longer than 14 days.

Adverse Reactions of Ribomycin Sulfate Injection

Occasionally rash, numbness, tinnitus, headache, nausea, vomiting, diarrhea, etc., individual hearing loss, dizziness, vitamin B or vitamin B deficiency, blood urea nitrogen and elevated blood aminotransferase can occur. Occasionally shock reports.

Contraindications to Ribomycin Sulfate Injection

1. Renal dysfunction is disabled.
2. Disable pregnant women.
3. Disabled for infants and young children.

Precautions for ribomycin sulfate injection

1. Cross-allergy, patients who are allergic to other aminoglycosides are also allergic to this product.
2. The following situations should be used with caution:
(1) Dehydration, as the concentration of blood drug increases, the possibility of toxic reaction increases;
(2) The 8th pair of brain nerve damage can cause damage to the auditory nerve and vestibular function;
(3) Myasthenia gravis or Parkinson's disease can cause neuromuscular blockade, resulting in skeletal muscle weakness;
(4) Renal function impairment should be adjusted according to the degree of renal function impairment or dose interval.
3 Interference to diagnosis: can increase the measured values of alanine aminotransferase, aspartate aminotransferase, serum bilirubin concentration and serum lactate dehydrogenase concentration; blood calcium, blood magnesium, blood potassium, blood sodium The measured value of the concentration may decrease.
4 Patients should be monitored:
(1) Vestibular function test, to test the vestibular toxicity before and during the periodical and long-term administration;
(2) Routine urine test and renal function measurement. The renal function should be measured regularly before and during the medication to prevent serious renal toxicity.

Ribomycin sulfate injection for pregnant and lactating women

Because this product may cause the 8th pair of cerebral nerve damage in newborns, pregnant women should be disabled.

Ribomycin sulfate injection for children

Because this product may cause damage to the auditory nerve and vestibular function, infants and young children are contraindicated. Use with caution.

Ribomycin sulfate injection for the elderly

Elderly patients may have various toxic reactions after applying this product, so attention should be paid to monitoring renal function (preferably to measure creatinine clearance); a smaller dose should be used to match the age, renal function, and function of the 8th pair of brain nerve Adaptation; audiogram testing should be performed before, during and after long-term medication.

Drug Interactions of Ribomycin Sulfate Injection

1. Combined with plasma substitutes such as dextran, glucose, sodium alginate and other nephrotoxic drugs, it will increase nephrotoxicity.
2. This product is used together with other aminoglycosides or successively applied locally or systemically, which can increase the possibility of ototoxicity, renal toxicity, and neuromuscular blockade.
3. This product combined with neuromuscular blockers can aggravate neuromuscular blockade, leading to muscle weakness, respiratory depression or respiratory paralysis.
4. Combined with capreomycin, cisplatin, uric acid, furosemide or vancomycin, or continuous local or systemic application may increase ototoxicity and renal toxicity.
5. Local or systemic use with cefalotin may increase renal toxicity.
6. Combined with polymyxin injections, or continuous local or systemic application, can increase renal toxicity and neuromuscular block effect.

Ribomycin sulfate injection overdose

This product has no special antagonists. If it is excessive or causes toxic reactions, it should be given a lot of water, and symptomatic therapy and supportive therapy should be used at the same time.

Pharmacology and Toxicology of Ribomycin Sulfate Injection

1. Pharmacology This product has a strong effect on most Gram-positive and negative bacteria. It has good antibacterial effect on Escherichia coli, Klebsiella pneumoniae, Proteus ordinary, Shigella and Salmonella, and its activity is slightly worse than kanamycin. It also has a good effect on some staphylococci, gonococci, meningococci, has a weak effect on streptococcus and tubercle bacillus, and has no effect on Pseudomonas aeruginosa, Pseudomonas aeruginosa, and anaerobic bacteria. This product is cross-resistant with kanamycin.
2. Ototoxicity test results in guinea pigs (guinea pigs), the hearing and cochlear pathological damage of guinea pigs is significantly lower than that of kanamycin and gentamicin.

Pharmacokinetics of ribomycin sulfate injection

This product is quickly and completely absorbed by intramuscular injection. The blood concentration of healthy people reaches a peak (25mg / L) within half an hour after intramuscular injection of 0.5g. It is widely distributed in the body, with high kidney concentration, certain contents in liver, spleen, muscle, milk and bone marrow, and the concentration of traditional Chinese medicine in cerebrospinal fluid is very low. It can pass through the placenta. After intramuscular injection, the concentration of umbilical cord blood is about half that of the mother's blood, and there is a considerable concentration in the eye tissue. It is mainly excreted by the kidney, and urinary excretion is 85% to 90% within 12 hours after administration.