What is holoposencephaly?

Holoprosencephaly (HPE) is a congenital congenital defect in which the brain cannot develop properly. The vast majority of fruits with holoposephalia spontaneously interrupted, with approximately one to two out of 10,000 surviving to birth. The severity of this innate defect can be quite diverse. Some individuals are so strictly disabled that they die shortly after birth, while others may be relatively normal, comparable to the development of other infants. Diabetic women are also more risk that children with holoposencephalia will have, especially if their blood sugar levels are not well controlled. Since the development of the brain begins to occur very soon, there must be conditions that can lead to holoposencephaly, present shortly after conception. There is no differentiation between the lobes in aliasum forms of this condition. This form is usually fatal. Other forms include Semilobar and Lobar, along with the middle hemispheric variant in which there is no fully differential in the middle of the brainost. Brain development problems can often be identified on ultrasound.

In addition to causing defects in the brain, holoposephalia also causes deformities of face and skull. In mild cases, the face may be at least affected, but conditions such as split lips and palaties are not unusual. The more serious deformities include a small or wrong skull, a missing or seriously malformed nose or a cyclopia in which a single eye is formed in the middle of the forehead.

If the diagnosis was omitted during prenatal care, the condition is usually evident at birth, due to the deformities of the face that occur in most cases. Different diagnostic tools can be used to confirm that a child has a holoposencephaly.

Infants with surviveable forms of this condition can experience developmental delays, seizures and apnea. This condition is not progressive, which means that after birth there will be no further damage and in children with milderIt is possible to achieve a high degree of intellectual development and independence. Children with this situation will need focused therapy and attention, with parents who will act as advocates to receive the care they need. Surgery can also be recommended to repair the abnormalities of the face to make the child feel more comfortable in society.