What are the different antidots for acetaminophen?

There are two medicinal antidots for acetaminophene, n-acetylcysteine ​​(NAC) and methionine. NAC is the usual antidote for acetaminophene, but methionine can be administered if NAC is not a viable option. Activated coal, highly porous form of carbon, can also be considered a universal antidote suitable for the treatment of overdose of acetaminophene in selected cases.

Acetaminophen, also known as paracetamol, is a drug used for the treatment of pain and reduction of fever. With different available forces and brands, there is a drug in many contradictory and prescription drugs, where it is usually combined with other drugs. Wide availability has made a drug primary cause of liver damage and liver failure, sometimes led to death. When the antidote is guaranteed, doctors usually take into account the time before the victim introduces treatment to determine which antidots to use for acetaminophen.

After adoption, oral acetaminofen quickly absorbs into the gastrointestinal (GI) tract and then into the bloodstream. When blood filterThe medicine over the liver is unfolded. A small amount of compound disintegrates into N-acetyl-P-Benzochinon imin (NAPQI), toxic by-product. This by -product is not a problem when consuming the drug at regular doses, because the liver naturally produces glutathion, chemical that neutralizes Napqi. However, overdose or regular consumption at higher than recommended levels causes more NAQI to produce and exhausts glutathion. As a result, liver or liver failure can occur if antidote for acetaminophene is not administered.

Coal activated is usually administered only when an overdose is treated immediately after the use of acetaminophene, usually within the first two hours. Hard -free without odor is normally mixed with water and administered orally, eITher by drinking or tube. Like the use of a dry sponge to suck water, coal attracts and binds most of the substance while it is still in the GI tract. This can prevent a dangerous level of NAPQI because less medicines are inde to the bloodstream and to the liver. Coal coal cannot be digested and the trapped drugs will be transferred through the GI tract before it is removed as waste.

Possible antidote for acetaminophene is a universal standard. The compound is a derivative of cysteine, amino acids found in food and naturally produced by the body. It seeks to increase the production of the body glutathione to render Inert Napqi. Although NAC is considered equally effective in oral or intravenous (IV) forms, it is more likely that IV will be an overdose that is unconscious, permanently vomiting, or bold to ensure the absorption of the drug. Studies suggest that NAC provides maximum toxicity protection when Given within 10 hours after overdose, but can be somewhat effective if it is received within 24 hours.

Antidots for acetaminophene also include methionine, oral medicine. This essential amino acid is not created by the body, but must be used from food sources or supplements. In the body, methionine is used to create CYStein, so it can also be beneficial for improving glutathion production. However, the drug has fewer clinical data that study its efficiency, and it seems that it has a drastic reduction in the protection of the liver if it takes 10 hours after an overdose. Therefore, its use is generally limited to emergency treatment that occurs outside medical facilities when NAC is not available.

with unintentional overdose is more likely that the victim will not be treated with antidotes for acetaminophene, as the symptoms may not be present immediately. If the treatment is delayed, the liver fails to fail to survive. If the overdose of acetaminophene may be suspected, it is essential that emergency medical assistance immediately begins to reduce the liver damage.