What narrows corticosteroids?
Corticosterides are synthetic drugs that mimic cortisol, the hormone produced by the adrenal gland. The prescribed sparingly due to short and long -term effects, patients must be shut down from these steroids gradually in a process called corticosteroid tapering. The rare of these drugs or the gradual reduction of the dose is necessary due to the serious symptoms of the selection to which they may occur. This drug works by reducing inflammation by reducing the production of inflammatory chemicals. It also suppresses the immune system by limiting the function of white blood cells. However, the main side effect of this treatment is that the adrenal gland ceases to produce cortisol naturally. Corticosteroid narrowing is essential for the body to allow sufficient cortisol to be produced. If the medicine is suddenly stopped, Thdrawal signs. In severe cases, this can lead to the exogenous insufficiency of the adrenal gland and the adrenal crisis. These symptoms may include joint and muscle pain, fatigue and nausea and vomiting. Some pacIenti also experience headaches, fever and low blood pressure. The risk of these symptoms and their degree of severity may be related to the dose and time the patient is taking the medicine.
The severity of these effects may be minimized by gradual narrowing, it takes weeks or even months. Longer and higher dose of corticosterides that the patient has taken affects the narrowing. For example, a proposed course for a patient of 40 milligrams would reduce the dose by 5 milligrams a week up to 20 milligrams. The dose would then be reduced by 2.5 milligrams a week. Óujes achieved 10 milligrams NCE 10 milligrams per week, the patient should be recommended to reduce by one milligrage a week until completion.
If it is avoided or rushed, exogenous adrenal insufficiency may occur. In this case, the adrenal glands are not able to produce sufficient cortisol fast enough, resulting in suppression of the axis HYPothalamic-ubophysis-Nadledvin. This then reduces the patient's ability to respond to stress due to shock, fatigue and low blood pressure. There are also pains and muscles, nausea and vomiting and general weakness.
If not treated, this can lead to the adrenal crisis, which is a life -threatening condition. Along with the symptoms of exogenous adrenal insufficiency, abdominal pain, confusion and increased rate of heart and airways occur. Common indicators are also rashes, dehydration and weight loss. If it is not treated, they may result in seizures, coma and death. Death occurs as a result of circulatory Collaps and the heart of arrhythmia. The main course of treatment of these conditions is to supply the body of corticosteroids again. As in the original treatment, the patients will again be recommended to follow the corticosteroid -tapping program.