What is perineurium?
Perineurium is a protective layer of tissue located around the nerves in the body and in the internal organs. It consists of concentric layers of connective tissue, which form a protective cloak around the bundles of nerve fibers. This structure is a transparent layer in the shape of a tube that easily pulls out of the bound nerves. Nerveurium coverage in the perineurium are part of the peripheral nervous system (PNS), which is responsible for transmitting messages from the central nervous system (CNS) in the brain into the shoulders, legs and internal organs.
Perineurium is part of three layers of tissue throughout the body. First, the individual nerve fibers in the peripheral nervous system are covered with a layer called endoneurium. Many of the fibers covered with endoneurium are then grouped together in groups called fascicles and covered with another protective layer of connective tissue, which is a perineurium. Several of these packages coated with perineurium are grouped with blood vessels and fat tissue and covered with another protective cloak called epineurium. FlattenedThe cells are arranged in layers and surrounded by collagen fibers and basement membrane. These specially shaped cells are able to prevent nerve fibers from stretching and help to create a blood barrier, which further provides protection of associated nerve fibers.
benign perineuriomas can form in nerve coverage. These small growth on the protective nerve case are very unusual. Some people with neurofibromas or malignant tumor of the peripheral nerve housing may have the results of diagnostic tests that show the involvement of perineurial cells. Malignant perineuriomas, along with other newborn cells in a person who was predated to cancer, can rarely develop on this layer.
If the Perineurium layer is damaged or torn, the nerves can transmit very painful signals to the central nervous system. Unprotected fascicles can grow together, whichIt is that nerve adhesions create that worsen the functionality of the nerve. A very thin layer of poly-lactide (PLA) with a porous patterned surface on one side is sometimes used to prevent the development of nerve adhesions after surgery. Nerves that are protected by an artificial sheath during the healing process show greater functional recovery than those not treated by this method.
When these adhesions develop, surgery may be required. The longitudinal cut to the perineurium is used to separate adhesion from nerve fibers and outer shell. Thin layers of poly-lactide film can be implanted through exposed nerve fibers after removal of adhesion.